The Structure of a Platinum(II) Complex of l-(fl-D-Arabinofuranosyi)eytosine
نویسنده
چکیده
The structure of a complex, arapen, formed between Pt ethylenediamine dichloride (PtenCl 2) and 1-(fl-Darabinofuranosyl)cytosine (ara-C) is described. The sugar puckering is C(2')-endo, and an intramolecular hydrogen bond connecting 0(2') to 0(5') in the sugar moiety is observed, a feature seen in the structure of neutral ara-C. The possible implications of the structure to reactivity studies of the complex with nucleic acid components are discussed. [Crystal data: (CI~H2~NsOsPtCI)+CI -, space group P21212, a = 24.440 (2), b = 10.388 (2), c = 6.700 (1) ,/~, Z = 4.]
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تاریخ انتشار 2001